Everee #4 - Post-menopause Support

Everee #4 contains Ovitage® the world’s most complete collagen derived from whole ovine skin and produced using a proprietary process that isolates all of the skin's important components, including structural proteins well beyond the collagen I and III common in traditional bovine and marine collagen products. 

This composition is boosted by the scientifically studied cGP-Pro, a cyclic glycine-proline complex extracted from New Zealand blackcurrant and stabilised by collagen. The result is a protein powder rich in specific amino acids ideally suited to support the body’s ability to deal with the challenges of post-menopause, from brain function to metabolic health and muscle maintenance. 

Muscle mass is harder to retain as we age. Branched-chain amino acids such as isoleucine, leucine and valine are important for building lean body mass (6), with leucine of particular importance for ageing females (17). Ovitage® in Everee #4 provides approximately 3x more of these crucial amino acids than traditional bovine and marine collagen and as a result assists in supporting muscle mass. In addition, high cystine proteins have demonstrated the ability to support to lean body mass.

Studies have shown a substantial increase in lean body mass as a result of diet high in peptides containing an oxidised form of cystine, compared to a dairy protein control (7). Ovitage® contains a substantially higher amount of oxidised cystine that conventional bovine and marine collagen and so supports lean muscle.

Ovitage® in Everee #4 is rich in glutamic acid, a form of glutamate and the most abundant transmitter in the nervous system. Glutamate is essential for normal brain function (14, 15). The impact of hormonal changes on this essential neurotransmitter have been reported in menopausal studies and good levels of glutamic acid from protein will support the maintenance of the appropriate balance of glutamate to support normal brain function (16).  

Cyclic glycine-proline (cGP-Pro) in Everee #4 has been shown to support normal brain function in people with Parkinsons disease. cGP-Pro supports Insulin-Like Growth Factor-1 (IGF-1), a hormone important for normal brain function (18). The function of IGF-1 starts to decline around 45 years of age, and IGF-1 deficiency is closely related to the onset and progression of age-related neurodegenerative conditions. In response to declining IGF-1, the body’s demand for cGP increases and studies show cGP-Pro supports IGF-1 availability. 

Recent scientific research on high cysteine proteins have shown significant impact on glucose clearance rates in type 2 diabetic patients (19) as well as improving insulin sensitivity. This is based on the impact of cysteine on metabolic pathways involving glutathione and other sulfur based amino acids. Ovitage® in Everee #4 has substantially higher sulfur amino acids than any other collagen and provides the important amino acids for the glutathione pathway, supporting glucose metabolism metabolic health.  

Further, published research on the mechanism of cyclic glycine-proline found in cGP-Pro provide further support for Everee #4 supporting insulin management and metabolic health by through IGF-1 and its metabolite IGFBP-3 (20).  

The cyclic glycine-proline found in the cGP-Pro present in Everee #4 supports blood pressure as a result of supporting IGF-1 levels (21). The role of IGF-1 in microvascularisation is well established, and the support for blood flow resulting from vascular flow, in particular around the brain, further supports blood pressure and cardiac health.