Everee #4 - Post-menopause Support

What it does

Everee Women™ #4 Post-menopause Support is designed for women embracing their post-menopause year with vitality and a renewed focus on self-care. Featuring Ovitage® Collagen and boosted by the clinically proven cGP-Pro extract from New Zealand blackcurrant, this protein powder is rich in specific amino acids ideally suited to boost the body's ability to deal with the challenges of post-menopause, from brain function through to metabolic health and muscle maintenance.

Muscle Maintenance: Our unique formula, rich in cystine and branched-chain amino acids, supports the production of lean muscle mass, helping you stay strong and active.
Cognitive Support: Tyrosine and glutamic acid enhance mental acuity and focus, keeping your mind sharp and alert.
Bone Health: The world's most complete collagen, Ovitage®, works synergistically to maintain optimal bone density.
Metabolic Health: Supports healthy blood sugar levels.
Heart Health: Promotes cardiovascular wellness for a vibrant, active lifestyle.

Why Choose Everee Women™ #4

Embrace this new chapter of life with confidence and vitality. Everee Women™ #4 Post menopause Support is more than just a supplement – it's your partner in maintaining optimal health and wellness during your post-menopausal years. Rediscover your vigour and take control of your health with Everee Women™ #4 Post-menopause Support.

• Comprehensive Formula: Addresses multiple concerns specific to women post-menopause in one convenient supplement.
• High-Quality Ingredients: Entirely made from New Zealand sources and formulated by New Zealand’s leading protein extraction scientists to ensure maximum bioavailability and effectiveness.
• Easy to Incorporate: Designed for busy lifestyles with a simple, ‘any way you want to take it’ approach that can be easily incorporated into your diet.

Real Science & Real Results - How It Does It

Everee Women™ #4 contains Ovitage® the world’s most complete collagen derived from whole ovine skin and produced using a proprietary process that isolates all of the skin's important components, including structural proteins well beyond the collagen I and III common in traditional collagen products. This functionality is boosted by the clinically proven cGP-Pro, a cyclic glycine-proline complex extracted from New Zealand blackcurrant and stabilised by collagen. The result is a protein powder rich in specific amino acids ideally suited to boost the body’s ability to deal with the challenges of post-menopause, from brain function to metabolic health and muscle maintenance

Muscle Maintenance   

Muscle mass is harder to retain as we age. Branched-chain amino acids such as isoleucine, leucine and valine are essential for building lean body mass (1), with leucine of particular importance for ageing females (2). Ovitage® in Everee Women™ #4 provides approximately 3x more of these crucial amino acids than traditional collagen and as a result assists in retaining muscle mass. In addition, high cystine proteins have demonstrated the ability to contribute further to lean body mass. Studies have shown a substantial increase in lean body mass as a result of a high cystine protein diet, compared to a dairy protein control (3). Ovitage® contains substantially higher cystine that conventional collagen and so supports this lean muscle development. 

Cognitive Support

Ovitage® in Everee Women™ #4 is rich in glutamic acid, a form of glutamate and the most abundant transmitter in the nervous system. Glutamate is essential for healthy brain function and cognitive performance (4, 5).  The impact of hormonal changes on this essential neurotransmitter have been reported in menopausal studies and good levels of glutamic acid from protein help maintain the appropriate balance of glutamate to boost brain function cognition and GABA for calming and anxiety relief (6). 
Cyclic glycine-proline (cGP-Pro) in Everee 4 has been shown to improve brain function in patients suffering Parkinsons disease. cGP-Pro normalises Insulin-Like Growth Factor-1 (IGF-1) a hormone that is responsible for brain development, memory and cognition, metabolism, and recovery from brain injury (7). The function of IGF-1 starts to decline around 45 years of age, and IGF-1 deficiency is closely related to the onset and progression of age-related neurodegenerative conditions. In response to declining IGF-1, the body’s demand for cGP increases and studies show cGP-Pro addresses this demand and so improves IGF-1 availability.

Metabolic Health

Recent clinical trials on high cysteine proteins have shown significant impact on glucose clearance rates in type 2 diabetic patients (8) as well as improving insulin sensitivity. This is based on the impact of cysteine on metabolic pathways involving glutathione and other sulfur based amino acids. Ovitage® in Everee 4 has substantially higher cysteine than any other collagen and provides the essential amino acids for this proven mechanism for controlling glucose metabolism related to weight management and metabolic health. 

Further, published studies on the mechanism of cyclic glycine-proline found in cGP-Pro provide further support for Everee Women™ #4 contributing to insulin management and metabolic health by controlling IGF-1 and its metabolite IGFBP-3 (9). 

Heart Health 

The cyclic glycine-proline found in the cGP-Pro of Everee 4 reduces blood pressure and improves diabetic peripheral neuropathy as a result of improving IGF-1 levels (10). The role of IGF-1 in microvascularisation is well established, and the improvement in blood flow resulting from improved vascular flow, in particular around the brain, further reduces the impact of blood pressure and improves overall cardiac health.

Dosage

Recommended daily dose of Everee 4 is 7.5g. Traditional collagens are established as effective in the range 2.5-15g (11) with 15g effective for improving lean body mass in women. The multiplying impact of the high cystine component of Everee Women™ #4 is to stimulate greater protein synthesis (12), providing effectiveness at the lower dosage range compared to conventional collagen. Each dose contains 100mg of cGP-Pro, the therapeutic dose of cyclic glycine-proline proven in clinical trials (7). 

References

1. Dudgeon WD, Kelley EP, Scheett TP. In a single-blind, matched group design: branched-chain amino acid supplementation and resistance training maintains lean body mass during a caloric restricted diet. J Int Soc Sports Nutr. 2016 Jan 5;13:1. doi: 10.1186/s12970-015-0112-9. PMID: 26733764; PMCID: PMC4700774.
2. Bauer JM, Verlaan S, Bautmans I, Brandt K, Donini LM, Maggio M, McMurdo ME, Mets T, Seal C, Wijers SL, Ceda GP, De Vito G, Donders G, Drey M, Greig C, Holmbäck U, Narici M, McPhee J, Poggiogalle E, Power D, Scafoglieri A, Schultz R, Sieber CC, Cederholm T. Effects of a vitamin D and leucine-enriched whey protein nutritional supplement on measures of sarcopenia in older adults, the PROVIDE study: a randomized, double-blind, placebo-controlled trial. J Am Med Dir Assoc. 2015 Sep 1;16(9):740-7. doi: 10.1016/j.jamda.2015.05.021. Epub 2015 Jul 10. PMID: 26170041.
3. Crum EM, McLeay YD, Barnes MJ, Stannard SR. The effect of chronic soluble keratin supplementation in physically active individuals on body composition, blood parameters and cycling performance. J Int Soc Sports Nutr. 2018 Sep 27;15(1):47. doi: 10.1186/s12970-018-0251-x. PMID: 30261892; PMCID: PMC6161438.
4. Zhou Y, Danbolt NC. Glutamate as a neurotransmitter in the healthy brain. J Neural Transm (Vienna). 2014 Aug;121(8):799-817. doi: 10.1007/s00702-014-1180-8. Epub 2014 Mar 1. PMID: 24578174; PMCID: PMC4133642
5. Alexander S, Glutamate, Encyclopaedia of Neuroscience, 2009, 885-594. doi.org/10.1016/B978-008045046-9.00682-3.
6. Braden BB, Kingston ML, Koenig EN, Lavery CN, Tsang CW, Bimonte-Nelson HA. The GABAA antagonist bicuculline attenuates progesterone-induced memory impairments in middle-aged ovariectomized rats. Front Aging Neurosci. 2015 Aug 14;7:149. doi: 10.3389/fnagi.2015.00149. PMID: 26321945; PMCID: PMC4536389.
7. 2018 Fan D, Alamri Y, Liu K, MacAskill M, Harris P, Brimble M, et al.
   Supplementation of Blackcurrant Anthocyanins Increased Cyclic Glycine-Proline in the Cerebrospinal Fluid of Parkinson’s Patients: Potential Treatment to Improve Insulin-Like Growth Factor-1 Function. Nutrients 2018;10:714. doi:10.3390/nu10060714.
8. Dias 1. W.M. Peeters, M. Gram, G.J. Dias, M.C.M. Vissers, M.B. Hampton, N. Dickerhof, A.E. Bekhit, M.J. Black, J. Oxbøll, S. Bayer, M. Dickens, K. Vitzel, P.W. Sheard, K.M. Danielson, L.D. Hodges, J.C. Brønd, J. Bond, B.G. Perry, L. Stoner, J. Cornwall, D.S. Rowlands, Changes to insulin sensitivity in glucose clearance systems and redox following dietary supplementation with a novel cysteine-rich protein: A pilot randomized controlled trial in humans with type-2 diabetes, Redox Biology, Volume 67, 2023, 102918, ISSN 2213-2317, https://doi.org/10.1016/j.redox.2023.102918.
9. Guan J, Gluckman Pd, Yang Pz, Krissansen G, Sun K, Zhou Y, Wen Jy, Shorten P, Wake G, Mcmahon Cd, Thomas Mf, Philip G, Chen W, S Moon, A Ren and Liu DX, Cyclic glycine-proline regulates IGF-1 homeostasis by altering the binding of IGFBP-3 to IGF-1 Scientific Report-Nature. 2014, 4, 4388.
10. Li FX, Liu K, Gray C, Harris P, Reynolds C, Vickers M and Guan J. Cyclic glycine-proline normalizes systolic blood pressure in high-fat diet-induced obese male rats. Nutrition, Metabolism & Cardiovascular Diseases. 30: 339-346.
11. Jendricke P, Centner C, Zdzieblik D, Gollhofer A, König D. Specific Collagen Peptides in Combination with Resistance Training Improve Body Composition and Regional Muscle Strength in Premenopausal Women: A Randomized Controlled Trial. Nutrients. 2019 Apr 20;11(4):892. doi: 10.3390/nu11040892. PMID: 31010031; PMCID: PMC6521629.
12. Tang L, Ollague Sierra J, Kelly R, Kirsner R S, Li J, Wool-derived keratin stimulates human keratinocyte migration and types IV and VII collagen expression, Experimental Dermatology, 21, 5, 2012, DOI: 10.1111/j.1600-0625.2012.01505.x